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When diet and allopurinol alone aren’t enough to lower your uric acid, DUZALLO may be able to help. DUZALLO is a once-daily pill that lowers high uric acid, the root cause of gout.

Uric acid—everybody has it. But when serum uric acid (sUA) levels get too high, problems can arise. High uric acid is caused by the over-production and under-elimination of uric acid. For most people with gout, a significant reason why sUA levels remain too high is because the body does not get rid of enough uric acid. DUZALLO works differently from allopurinol because it contains two medicines in one pill to address both the under-elimination and over-production of uric acid.

  1. ALLOPURINOL reduces uric acid production
  2. LESINURAD helps the body eliminate uric acid

Understanding Side Effects

Discover important information about DUZALLO, including some of the most common side effects of treatment.

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Reduces
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There are several causes of gout, with the biggest being the uric acid your body makes. Allopurinol addresses one part of the problem. DUZALLO is the only treatment for high uric acid that works in 2 ways with 1 pill—it lowers the amount of uric acid the body makes, and increases the amount of uric acid the body gets rid of.

See how DUZALLO may lower your uric acid level

sUA

<6 mg/dL

The American College of Rheumatology guidelines recommend a goal sUA of less than 6 mg∕dL for all patients with gout.

DUZALLO helped nearly twice as many gout patients reach their uric acid goal compared with allopurinol alone.*

DUZALLO is proven to work. Its benefits are supported by two clinical studies.*

Important Safety Information

DUZALLO can cause serious side effects, including:

Kidney Problems: Some people taking DUZALLO may have kidney problems, such as a sudden decrease in kidney function (acute kidney failure). Your healthcare provider may do blood tests to check your kidneys while you are taking DUZALLO.

Serious Skin Rash and Serious Allergic Reactions: Severe and potentially life-threatening allergic reactions and skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and exfoliative dermatitis, have been reported in some people taking allopurinol, one of the components of DUZALLO. Stop taking DUZALLO and get emergency medical help if you have any of the following symptoms:

  • skin rash; blistering of the skin, mouth, nose, and genitals
  • painful red or purple skin that looks burned and peels off
  • joint pain; swollen glands
  • red, painful, watery eyes; persistent itching; hives
  • fever

Do not take DUZALLO if you have severe kidney problems, have received a kidney transplant or are on dialysis, have a fast breakdown of cancer cells that can lead to high uric acid (tumor lysis syndrome), have a rare inherited condition that causes too much uric acid in the blood (Lesch-Nyhan syndrome), or had a skin rash or other allergic reaction after taking allopurinol.

Liver Problems: Liver problems can happen in people who take DUZALLO. Call your healthcare provider if you have any of the following symptoms: loss of appetite, weight loss, feeling very tired, nausea or vomiting, yellowing of your skin or the white part of your eyes, itching, dark or brown (tea-colored) urine, or pain on the upper right side of your stomach.

Heart Problems: People who take DUZALLO can have serious heart problems, including heart attack and stroke. It is not known that DUZALLO causes these problems.

Blood Problems: DUZALLO can affect your bone marrow and cause low red blood cells, white blood cells, and platelets. If your blood cell counts become very low, you can get infections or have bleeding problems. Taking DUZALLO with certain other medicines can increase your chance of having blood problems.

Drowsiness: DUZALLO can cause you to be drowsy. Do not drive, operate heavy machinery, or do other dangerous activities until you know how DUZALLO affects you.

The most common side effects of DUZALLO include headache, flu, higher levels of blood creatinine (a measure of kidney function), heartburn (acid reflux), skin rash, nausea, and diarrhea. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUZALLO. For more information, ask your healthcare provider or pharmacist.

What is DUZALLO?

DUZALLO is a prescription medicine that contains 2 medicines, a URAT1 inhibitor called lesinurad and a xanthine oxidase inhibitor called allopurinol. DUZALLO is used to lower uric acid levels in the blood in people with gout, when allopurinol alone has not worked well enough.

Please see Medication Guide and full Prescribing Information, including Boxed Warning.

Ironwood Contact Center for general inquiries: 1-844-374-4793.

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Important Safety Information

DUZALLO can cause serious side effects, including:

Kidney Problems: Some people taking DUZALLO may have kidney problems, such as a sudden decrease in kidney function (acute kidney failure). Your healthcare provider may do blood tests to check your kidneys while you are taking DUZALLO.