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Introducing DUZALLO®

A new treatment for high uric acid,
the root cause of gout

For people who have not achieved target uric acid levels with allopurinol alone, DUZALLO may be an option.

DUZALLO is the first and only medicine for people with gout that treats high uric acid in two ways with one pill. It helped nearly twice as many gout patients reach their uric acid goal compared with allopurinol alone.* Talk to your doctor to see if DUZALLO may be an option for you.

Save on your DUZALLO co-pay
Visit the DUZALLO Savings Program website to learn more about how eligible patients may save on their out-of-pocket costs.† For additional savings inquiries, call 1-855-636-9116. For general inquiries, call the Ironwood Contact Center at 1-844-374-4793.

*Studies used lesinurad and allopurinol taken separately.
†Subject to eligibility. Restrictions apply.

DUZALLO is different because it contains not one, but two medicines proven to help lower uric acid

ALLOPURINOL

reduces uric acid production

+

LESINURAD

increases the amount of uric acid eliminated by the body

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Important Safety Information

DUZALLO can cause serious side effects.

Kidney problems: Some people taking DUZALLO may have kidney problems such as a sudden decrease in kidney function (acute kidney failure). Your healthcare provider may do blood tests to check your kidneys while you are taking DUZALLO.

Serious skin rash and serious allergic reactions: Severe and potentially life-threatening allergic reactions and skin reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis and exfoliative dermatitis have been reported in some people taking allopurinol, one of the components of DUZALLO. Stop taking DUZALLO and get emergency medical help if you have any of the following symptoms:

  • skin rash; blistering of the skin, mouth, nose, and genitals
  • painful red or purple skin that looks burned and peels off
  • joint pain; swollen glands
  • red, painful, watery eyes; persistent itching; hives
  • fever

Liver Problems: Liver problems can happen in people who take DUZALLO. Call your healthcare provider if you have any of the following symptoms: loss of appetite, weight loss, feeling very tired, nausea or vomiting, yellowing of your skin or the white part of your eyes, itching, dark or brown (tea-colored) urine, or pain on the upper right side of your stomach.

Heart Problems: People who take DUZALLO can have serious heart problems including heart attack and stroke. It is not known that DUZALLO causes these problems.

Blood Problems: DUZALLO can affect your bone marrow and cause low red blood cells, white blood cells and platelets. If your blood cell counts become very low, you can get infections or have bleeding problems. Taking DUZALLO with certain other medicines can increase your chance of having blood problems.

Drowsiness: DUZALLO can cause you to be drowsy. Do not drive, operate heavy machinery, or do other dangerous activities until you know how DUZALLO affects you.

The most common side effects of DUZALLO include headache, flu, higher levels of blood creatinine (a measure of kidney function), heartburn (acid reflux), skin rash, nausea, and diarrhea. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUZALLO. For more information, ask your healthcare provider or pharmacist.

What is DUZALLO?

DUZALLO is a prescription medicine that contains 2 medicines, a URAT1 inhibitor called lesinurad and a xanthine oxidase inhibitor called allopurinol. DUZALLO is used to lower uric acid levels in the blood in people with gout, when allopurinol alone has not worked well enough.

Please see Medication Guide and full Prescribing Information, including Boxed Warning.

Important Safety Information

DUZALLO can cause serious side effects.

Kidney problems: Some people taking DUZALLO may have kidney problems such as a sudden decrease in kidney function (acute kidney failure). Your healthcare provider may do blood tests to check your kidneys while you are taking DUZALLO.

Serious skin rash and serious allergic reactions: Severe and potentially life-threatening allergic reactions and skin reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis and exfoliative dermatitis have been reported in some people taking allopurinol, one of the components of DUZALLO. Stop taking DUZALLO and get emergency medical help if you have any of the following symptoms:

  • skin rash; blistering of the skin, mouth, nose, and genitals
  • painful red or purple skin that looks burned and peels off
  • joint pain; swollen glands
  • red, painful, watery eyes; persistent itching; hives
  • fever

Liver Problems: Liver problems can happen in people who take DUZALLO. Call your healthcare provider if you have any of the following symptoms: loss of appetite, weight loss, feeling very tired, nausea or vomiting, yellowing of your skin or the white part of your eyes, itching, dark or brown (tea-colored) urine, or pain on the upper right side of your stomach.

Heart Problems: People who take DUZALLO can have serious heart problems including heart attack and stroke. It is not known that DUZALLO causes these problems.

Blood Problems: DUZALLO can affect your bone marrow and cause low red blood cells, white blood cells and platelets. If your blood cell counts become very low, you can get infections or have bleeding problems. Taking DUZALLO with certain other medicines can increase your chance of having blood problems.

Drowsiness: DUZALLO can cause you to be drowsy. Do not drive, operate heavy machinery, or do other dangerous activities until you know how DUZALLO affects you.

The most common side effects of DUZALLO include headache, flu, higher levels of blood creatinine (a measure of kidney function), heartburn (acid reflux), skin rash, nausea, and diarrhea. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUZALLO. For more information, ask your healthcare provider or pharmacist.

What is DUZALLO?

DUZALLO is a prescription medicine that contains 2 medicines, a URAT1 inhibitor called lesinurad and a xanthine oxidase inhibitor called allopurinol. DUZALLO is used to lower uric acid levels in the blood in people with gout, when allopurinol alone has not worked well enough.

Please see Medication Guide and full Prescribing Information, including Boxed Warning.